Integration is at random except in rare cases in which hbv integration at specific sites has been shown to activate endogenous genes such as retinoic acid b. Save powerpoint presentations as pdf files office support. Hcv is a major health problem, almost 350 million individuals are chronically hcv infected and 10% of the pakistani population is chronically infected with this viral pathogen. Liver cancer ppt free download as powerpoint presentation.
The diagnosis of hcc can be difficult and often requires the use of one. Screening, diagnosis, and treatment catherine frenette, md california pacific medical center the barry s. Its different from secondary liver cancers, which have spread to the liver from other organs. Diagnosis, staging and treatment of hepatocellular carcinoma. People can view the slides even if they dont have powerpoint, but they cant make changes to it. In the publish as pdf or xps dialog box, choose a location to save the file to. Nccn believes that the best management for any patient with cancer is in a clinical trial. Hepatitis c virus to hepatocellular carcinoma infectious. Hepatocellular carcinoma definition of hepatocellular. Although the mainstay of therapy is surgical resection, the. Download the easl guideline for management of hepatocellular carcinoma as pdf or ppt slide deck. Nevertheless, children with biliary atresia, infantile cholestasis, glycogenstorage diseases, and a wide array of cirrhotic liver diseases are predisposed to developing hepatocellular carcinoma. Recently liver resection for hcc and significant cirrhosis has become increasingly popular.
Hepatocarcinoma definition of hepatocarcinoma by the. Hepatocarcinoma with sarcomatoid transformation is uncommon. Hepatocellular carcinoma hcc is an aggressive tumor that often occurs in the setting of chronic liver disease and cirrhosis see epidemiology and risk factors for hepatocellular carcinoma. Nccn clinical practice guidelines in oncology nccn. Hypercalcemia occurs when calcium levels in the blood become elevated. Hepatitis c virus causes acute and chronic hepatitis an can leads to hcc via oxidative stress, insulin resistance ir, fibrosis, liver cirrhosis and hcv induced steatosis.
Hepatocellular carcinoma surgery in india to treat liver cancer forerunners health care pioneers in health tourism advanced cancer departments provide hepatocellular carcinoma surgery in india with the best standards of indian private healthcare system that can be truly described as being stateoftheart. Introduction hepatocellular carcinoma hcc is a primary tumor of the liver that usually develops in the setting of chronic liver disease, particularly in patients with cirrhosis and chronic hepatitis b virus or hepatitis c virus infection. Diagnosis alphafetoprotein afp alphafetoprotein levels may be assessed by a blood test. Tace represents the current standard for unresectable bclc stage b patients not eligible for lt. Suny downstate medical center, dept of veterans affairs, new york harbor health system december 16, 2016. Hepatocellular carcinoma is now increasingly common malignancy that is faced now a millions of people around the world. Causes primary sclerosing cholangitis there is a high incidence of cholangiocarcinoma in patients figure 7 with ulcerative colitis 1 in 256 and primary sclerosing cholangitis 420%. Hepatocarcinoma definition of hepatocarcinoma by medical.
The uicc tnm prognostic factors project recognizes that not all cancer registries will be able to stage new cancer cases diagnosed from january the 1st 2018 with tnm 8th edition but that physician may. Most people who have a liver hemangioma never experience signs and symptoms and dont need treatment. A form of cancer, carcinoma makes up the majority of the cases of malignancy of the breast, uterus, intestinal tract, skin, and tongue. The 2018 esmo clinical practice guidelines on hepatocellular carcinoma hcc are conceived to provide the standard approach to diagnosis and local and systemic treatment of hcc. We report a 40 yearold male that presented pain in. Cholangiocarcinoma ppt liver gastroenterology free 30.
Jan 30, 2012 hepatitis c virus causes acute and chronic hepatitis and can lead to permanent liver damage and hepatocellular carcinoma hcc in a significant number of patients via oxidative stress, insulin resistance ir, fibrosis, liver cirrhosis and hcv induced steatosis. Human hookworm canada pdf ppt case reports symptoms. Hepatocellular carcinoma is now the third leading cause of cancer deaths worldwide, with over 500,000 people affected. Mar 12, 2020 hepatocellular carcinoma hcc is an aggressive hepatic neoplasm that most commonly affects adults. Di bisceglie from the division of gastroenterology and hepatology, department of internal medicine, saint louis university school of medicine, st. Hepatocellular carcinoma in pregnancy withunusual presentations.
We report a case of hepatocellular carcinoma presenting as gastric outlet obstruction in a 64 years male with chronic hepatitis b virus. Joon koo han, byung ihn choi, ah young kim, su kyung an, joon woo lee, tae kyung kim, sunwhe kim. The major risk factor for development of hepatocellular carcinoma is cirrhosis, particularly cirrhosis related to chronic viral hepatitis, alcoholic cirrhosis, cirrhosis caused by hemochromatosis, and primary biliary cirrhosis. Specific interaction between drug and its receptor at the molecular level.
The following hepatocellular carcinoma guideline will give uptodate advice for the clinical management. Ppt version pdf version souto, bernardino geraldo alves the decentralization of care to persons living with hiv to the primary attention can be an alternative to sustainability and humanization of the brazilian program for the control of hivaids. Aug 24, 2015 hepatocellular carcinoma is now increasingly common malignancy that is faced now a millions of people around the world. For patients with hcc in cirrhosis lt is the treatment of choice. Advantages of tumor vasculature targeting over tumor cell targeting easy access to target cells upon i. Click create pdf xps document, then click create pdf xps. Taking the pathological approach first, the term early implies that a lesion is at a relatively early stage of carcinogenesis and. A correction has been published annals of oncology, mdy510 nb. Antiviral therapies should follow the easl guidelines for management of chronic hepatitis b and c infection. Diagnostic accuracy is crucial, particularly in the current. Treatment include corticosteroid medication, laser treatment, medicated gel,surgical removal surgery to remove the liver. Levin department of transplantation a free powerpoint ppt presentation displayed as a flash slide show on id.
Identification of the site of origin of carcinoma of unknown primary using immunohistochemistry is a frequent requirement of anatomic pathologists. Another common presentation of hcc is hepatic decompensation in a patient with known mild cirrhosis or. Liver cancer articles case reports symptoms treatment, india. Hepatocellular carcinoma hcc clinical presentation. Each year, hepatocellular carcinoma is diagnosed in more than half a million people worldwide, including approximately 20,000 new cases in the united states. Hepatocellular carcinoma is the most frequent primary liver cancer and is an important medical problem.
Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Early hepatocellular carcinoma hcc can be described as early according to its pathological characteristics as well as its clinical characteristics. Symptoms are nonspecific and can include depression, confusion, difficulties in concentrating, hypertension, constipation, nausea, fatigue, andor muscle weakness. The changes noted in the above correction have been incorporated into the manuscript displayed below. Panel d shows a large mass more than 10 cm in diameter and ascites arrows, indicating advancedstage hepatocellular carcinoma. Management of hepatocellular carcinomaq european association for the study of the liver. Practical applications in immunohistochemistry carcinomas of unknown primary site patricia l. The figure above shows the hepatocellular carcinoma average annual incidence rate, by sex in the united states from 20012006. Louis, missouri hepatocellular carcinoma is the most frequent primary.
Hepatocarcinoma victor camarao porto academico do 8. Hcv induced steatosis and oxidative stress causes steatohepatitis and these pathways lead to liver injury or hcc in chronic hcv. Certain diseases, such as hemochromatosis and alpha. Powerpoint is the worlds most popular presentation software which can let you create professional liver cancer hepatocellular carcinoma powerpoint presentation easily and in no time. Liver hemangioma is a non cancerous benign mass that occurs in the liver. A liver hemangioma is made up of a tangle of blood vessels. Hepatocarcinoma definition of hepatocarcinoma by the free. Liver hemangioma is a noncancerous benign mass that occurs in the liver. Panel c shows multiple hepatocellularcarcinoma nodules arrows in a patient with childpugh class b cirrhosis, indicating intermediatestage disease. Pembrolizumab was effective and tolerable in patients with advanced hepatocellular carcinoma who had previously been treated with sorafenib. Introduction investigations pathogenesis management clinical prevention features 3. This helps you give your presentation on liver cancer hepatocellular carcinoma in a conference, a school lecture, a business proposal, in a webinar and business and professional representations.
Hepatocellular carcinoma is a cancer that starts in your liver. This drug is undergoing further assessment in two phase 3, randomised trials as a secondline treatment in patients with hepatocellular carcinoma. Hcc tumorigenesis is relatively silent and patients experience late symptomatic presentation. Liver hemangioma is sometimes called hepatic hemangioma or cavernous hemangioma. Hepatocellular carcinoma is the fifth most common cancer worldwide, and its incidence is rising in many countries, including the united states. Initial presentation 69m with pmh of htn, hiv on haart, hcv. With 782 000 cases diagnosed and 746 000 deaths in 2012, and an ageadjusted worldwide incidence of 101 cases per 100 000 personyears, hepatocellular carcinoma is ranked as the sixth most common neoplasm and the third leading cause of cancer death. Welldifferentiated hcc, however, may be difficult to distinguish from normal hepatic parenchyma or hepatocellular adenomas. Diagnosis, staging, and management of hepatocellular carcinoma. Hepatocellular carcinoma easl guideline easlthe home of. Tnm classification of malignant tumours 8th edition. Tnm8 the tmn 8th edition is being published in december 2017. Hepatocellular carcinoma represents about 90% of primary liver can. A free powerpoint ppt presentation displayed as a flash slide show on id.
Participation in clinical trials is especially encouraged. It is typically diagnosed late in its course, and the median survival following diagnosis is approximately 6 to 20 months. Cholangiocarcinoma ppt free download as powerpoint presentation. Hepatocellular carcinoma surgery in indi authorstream. Also it is the second most frequent cause of cancerrelated death globally. When you save presentation as a pdf file it freezes the formatting and layout. Mar 30, 2020 hepatocellular carcinoma hcc is a primary malignancy of the liver. Pictorial essay of ct and cholangiographic findings. We compare the value of tace to liver resection for patients with bclc stage a and b hcc.
Liver cancer may also be linked to obesity and fatty liver disease. A rapidly growing tumor requires various nutrients and vitamins. Almost 90% of all cases are caused by primary hyperparathyroidism hpt or hypercalcemia of malignancy. Free download liver cancer hepatocellular carcinoma. A liver hemangioma made up tangle of blood vessels. Hepatocellular carcinoma hcc is an aggressive hepatic neoplasm that most commonly affects adults.
Treatment strategies for hepatocellular carcinomaa. The 2 pathologic subtypes are classic hepatocellular carcinoma and fibrolamellar carcinoma. In these regions, hcc may develop among young patients, even when they do not. Hepatocellular carcinoma represents about 90% of primary liver cancers and constitutes a major global health problem. Hepatocellular carcinoma hcc is the most common type of primary liver cancer in adults, and is the most common cause of death in people with cirrhosis it occurs in the setting of chronic liver inflammation, and is most closely linked to chronic viral hepatitis infection hepatitis b or c or exposure to toxins such as alcohol or aflatoxin. Pathology outlines hepatocellular carcinoma general. Hepatitis b and c and hemochromatosis can cause permanent damage and liver failure. The high incidence of primary liver cancer in east asia and southeast asia is largely attributable to the high prevalence of chronic hbv infection in these regions. Alphafetoprotein afp is a tumor marker that is elevated in 6070% of patients with hepatocellular carcinoma. These results indicate that pembrolizumab might be a treatment option for these patients. Pdf hepatocellular carcinoma hcc is a major health problem with a high incidence and mortality.
Note little is known about the hepatocarcinogenesis mechanisms which seem to differ according to the risk factor involved hbv impact in hbv carriers most hccs contain dna sequences integrated into the host chromosomal dna. Histopathology images of hepatocellular carcinoma by. See epidemiology and etiologic associations of hepatocellular carcinoma. Symptoms include pain in the upper right abdomen, feeling full after eating only a small amount of food, lack of appetite, nausea, vomiting. Introduction hepatocellular carcinoma hcc is an important, rare entity during pregnancy. Apr 08, 2016 hepatocellular carcinoma hcc is a common malignancy and now the second commonest global cause of cancer death. Hepatocellular carcinoma hcc is a primary malignancy of the liver. It consists of a myriad of individual microscopic functional units call lobules.
New recommendations are provided regarding the locoregional management and the systemic treatment with lenvatinib, regorafenib, cabozantinib, ramucirumab and the anti. Anatomy anatomy the liver is the largest organ in the abdominal cavity and the most complex. Ppt liver cancer hepatocellular carcinoma powerpoint. Nevertheless, children who are affected with biliary atresia, infantile cholestasis, glycogenstorage diseases, and a wide array of cirrhotic diseases of the liver are predisposed to developing hepatocellular carcinoma.
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